Vitamin B2 – Riboflavin

Vitamin B2, riboflavin, is our next stop on the B vitamin journey. Like all the B vitamins it is a water-soluble vitamin, meaning it has to be taken in daily because it will be excreted through urine and stool.

Riboflavin is very important for a lot of reasons that we’re going to discuss. It is critical  for turning food into usable energy, for detoxification, and for our immune system.

It is necessary for our skin hair and nails to grow and reproduce.

One of its most important jobs is working within the brain to improve cognitive function and as well as improve our neurotransmitters’ function.

So let’s dive in to a more detailed look at what B2 does within our body.

What does B2 Do??

Vitamin B2 metabolizes carbohydrates, fats, and proteins so that our body can turn glucose into energy used for all sorts of body functions. It has a huge place in the Krebs cycle  –  the process your body uses to turn blood sugar into ATP, our energy molecule. Consider it like a vehicle using fuel.

Vitamin B2 is important in some of the functions of our liver. It metabolizes different supplements and medications. Riboflavin is also very important in the development and use of glutathione, the biggest detoxification compound our body makes in the liver. B2 not only helps develop glutathione, but it also regenerates it so that your body can rid itself of toxins.

One of the biggest things that I have talked about with B2 over the years is its role in our cognitive function. There are many studies that show B2 is necessary in order to protect us from Alzheimer’s and dementia but also to keep our brains clear unable to think as we age. Riboflavin also helps with dopamine and serotonin metabolism which leads to stabilizing our moods. It has been found to reduce anxiety and improve depressive thoughts.

Recent studies have  found that riboflavin is very important in the metabolism of minerals, especially iron. Without B2, the body cannot break down iron from food, thus you can become anemic because the body does not have the riboflavin it needs to break the iron down. This causes a decrease in the number of red blood cells in your body leading to fatigue and muscle weakness.

Riboflavin is also a huge antioxidant in the body helping remove oxidative stress throughout the body, especially in the brain.

An interesting recent discovery about riboflavin is its role in those who have the gene mutation MTHFR, a very common gene mutation that interferes with the methylation process. Methylation is critical for detoxification, brain function and cardiovascular health. A good write up explaining methylation can be found at https://fullscript.com/blog/methylation.

 Those with the MTHFR gene are more prone to an increase in homocysteine levels. Homocysteine is an inflammatory marker that has been shown to be correlated with an increased risk for heart attack or stroke. Riboflavin actually helps lower homocysteine levels and reduces blood pressure in those with the MTHFR gene mutation.

Vitamin B2 is also a critical part of the metabolism of the other B vitamins folate, B6, and niacin, as well as iron as mentioned above. Riboflavin has also been linked to DNA repair.

As you can see, vitamin B2 is a critical part of our health even though it is not a nutrient that is talked about  in medical appointments and even more rarely checked on blood work.

What happens with Low B2?

What if your B2 levels aren’t optimal (hint: most aren’t lol)?

There are a lot of common symptoms that happen with lower vitamin B2, making it an important nutrient to be discussed and checked.

Some of the more common symptoms of low vitamin B2 are:

Do any of those ring true for you?

Vitamin B2 Foods

So where can we find B12 in our food? This is quite a list but B2 is common in healthy foods.

  • Liver
  • Dairy
  • Asparagus
  • Eggs
  • Dark green leafy vegetables
  • Meats
  • Almonds
  • Salmon and tuna
  • Avocados
  • Whole grains
  • Mushrooms
  • Brewer’s yeast
  • Soybeans
  • Broccoli
  • Brussels sprouts

Things to Consider

There are some things that interfere with the effectiveness of B2. While heat does not damage riboflavin, light can. It is best to keep any foods that are high in riboflavin out of direct light.

You don’t want to take B2 with copper, zinc, vitamin C, caffeine, or cilium because it won’t absorb. Absorption is also better if you are taking a supplement of B2 to take it with food. Alcohol  intake will slow the absorption of B2 just like its sister B1.

Drugs that can interfere with the absorption of B2 are anticholinergics (think meds that dry you out), antidepressants, antipsychotic medications and diuretics.

Supplementation

It is best to get vitamin B2 from foods, like everything else. But often we have to supplement B2 especially if you are not eating grains, dairy or meats.

When taking a supplement, the active form of B2 is the only one that will work for the body. When you look at the supplement facts on the label it should say riboflavin 5 phosphate. That is the form of B2 needed.

Dosing for vitamin B2 should be between 50 and 200 milligrams daily. I usually recommend 100 milligrams daily if you are taking it separately from a B complex. There are no real evidence that taking too much vitamin B2 can become toxic, however it is probably not needed.

It is unbelievable to me how incredibly intricate the human body is and how each of these small nutrients has its place in the inner workings of the body systems. Riboflavin is another critical vitamin to our overall heath and well-being. Let’s make sure your levels are where they need to be!!

References

Bland, J. et al (2004). Clinical Nutrition: a function approach.

Calton, M. & Calton, J. (2015). The Micronutrient Miracle.

Cohen, S. (2011). Drug Muggers. Rodale

Linus Pauling Institute (2024). https://lpi.oregonstate.edu/mic/vitamins/riboflavin

Power, H. (2003). Riboflavin (vitamin B-2) and health.

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